| 摘要 |
An electrical stimulation device is combined with a biologic to increase osteogenesis (i.e., bone healing or bone formation). The electrical stimulation is osteoblastic in that it produces new bone cells and or increases the activity of the existing cells, either osteoblasts or osteocytes. The preferred biologic decreases osteoclastic activity, which is the remodeling of bone usually by destroying the bone. Thus, osteogenesis is maximized by decreasing osteoclastic activity, while at the same time increasing osteoblastic activity. Osteogenesis can also be maximized by combining electrical stimulation with a BMP. Though BMPs are generally considered to increase osteoblastic activity, certain BMPs may have an additive effect to the use of electrical stimulation.
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