发明名称 |
ORAL DOSAGE FORMS COMPRISING A BENZIMIDAZOLE AND BUFFER |
摘要 |
The present invention relates to pharmaceutical preparations comprising substituted benzimidazole proton pump inhibitors. There is provided a liquid or solid pharmaceutical dosage form that is not enteric coated or delayed released containing a proton pump inhibitor and a Primary Essential Buffer, and an optional Secondary Essential Buffer. When the dosage form is placed in a liquid phase the Primary Essential Buffer maintains the pH of the environment at a value greater than the pKa of the proton pump inhibitor for a time sufficient to substantially avoid acid degradation of the proton pump inhibitor in the environment. Also provided is a method for treating acid-related gastrointestinal disorders by administering a solid pharmaceutical dosage form; and a kit for the preparation of a liquid oral pharmaceutical composition.
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申请公布号 |
CA2453117(C) |
申请公布日期 |
2010.06.29 |
申请号 |
CA20022453117 |
申请日期 |
2002.07.08 |
申请人 |
CURATORS OF THE UNIVERSITY OF MISSOURI |
发明人 |
PHILLIPS, JEFFREY O. |
分类号 |
A61K31/4439;A61K9/00;A61K9/20;A61K9/22;A61K9/24;A61K9/28;A61K9/46;A61K31/00;A61K31/198;A61K31/522;A61K33/00;A61K33/06;A61K36/00;A61K36/185;A61K36/42;A61K36/48;A61K36/534;A61K36/82;A61K36/898;A61K45/06;A61K47/02;A61K47/04;A61K47/12;A61P1/04;C07D401/12 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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