| 发明名称 |
5-Substituted-2-phenylamino benzamides as MEK inhibitors |
| 摘要 |
An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R1, R2, R3, R4, and X are the same as defined in the present patent application].
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| 申请公布号 |
US7745663(B2) |
申请公布日期 |
2010.06.29 |
| 申请号 |
US20050658533 |
申请日期 |
2005.07.26 |
| 申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
ISSHIKI YOSHIAKI;KOHCHI YASUNORI;MIZUGUCHI EISAKU;IIKURA HITOSHI;MATSUBARA YASUAKI;TSUJII SHINJI;SHIMMA NOBUO;MIWA MASANORI;AIDA SATOSHI;KOHCHI MASAMI;MURATA TAKESHI;ASO KOSUKE |
| 分类号 |
C07C239/00;A01N37/18;A61K31/16;A61K31/165;A61K31/535;C07C229/00;C07C233/00;C07C235/00;C07C237/00;C07C251/00;C07C259/00;C07D265/00 |
主分类号 |
C07C239/00 |
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