发明名称 4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine derivatives as tyrosine kinase and raf kinase inhibitors for the treatment of tumours
摘要 Compounds of the formula (I), in which R6, R7, R8, R9, Het1, X and X′ have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
申请公布号 US7745434(B2) 申请公布日期 2010.06.29
申请号 US20050667173 申请日期 2005.10.20
申请人 MERCK PATENT GMBH 发明人 HOELZEMANN GUENTER;ACKERMANN KARL-AUGUST;CRASSIER HELENE;JONCZYK ALFRED;RAUTENBERG WILFRIED;TARRASON GEMA;ROSELL-VIVES ELISABET;ADAN JAUME;CASES CLAUDIA
分类号 A61K31/535;A01N43/58;A01N43/60;A61K31/495;A61K31/50;C07D413/00;C07D471/00;C07D487/00 主分类号 A61K31/535
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