PATCH DRUG INCLUDING THE CROSS-LINKED DRUG-FREE HYDROGEL LAYER BY IRRADIATION

摘要

PURPOSE: A patch agent for the local anesthetic including a cross-linked drug free hydrated gel layer is provided to maintain patch form even in reduction of physical property. CONSTITUTION: A patch agent for the local anesthetic comprises a support layer(1), drug-containing hydrated gel layer(3) and peeling layer(4). The drug free hydrated gel layer(2) attached to the affected part opposite surface of the drug content hydrated gel layer is included. The drug free hydrated gel layer emits 30-70 % of the initial drug to the hydration according to the concentration of the drug contained in the drug content hydrated gel layer without the material property degradation of layer after the affected part attach within 1 hour. The drug content hydrated gel layer is the polyvinyl alcohol material of 5-40 weight%, and skin permeation enhancer of 1-20 weight%.