| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: there is offered application of Benzohexonium as a hypolipidemic agent. Previously, Benzohexonium was used as a ganglionic blocking agent in bronchiospasms, peripheral vasospasm, for reduction of hypertensic crisis, for controlled hypotension, in gastric ulcer and duodenal ulcer. It is shown that Benzohexonium reduces concentration of cholesterol and triglycerides in blood, liver, aorta, and considerably decreases the atherogenic index. The intensity of hypolipidemic effect of Benzohexonium enables to consider this agent as close to a common lipid lowering preparation Gemfibrozil and exceeds the fibrate effect of Clofibrate and Probucol. ^ EFFECT: preclinical trials of Benzohexonium ensure to recommend it as a hypolipidemic agent for prevention and treatment of atherogenic dislipoproteinemia. ^ 4 tbl |
