发明名称 |
METHOD FOR CONNECTIVE TISSUE DENSITY CORRECTION |
摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to medicine, namely to cardiology and can be used for connective tissue density correction following myocardial infarction and pericardiotomy. The method involves triple administration of an inhibitor of a polypeptide sequence containing fragments -Asp-Pro-Lys-Arg-Leu-Tyr-Cys-Asn-Gly-Gly-, -Glu-Arg-Gly-Val-Val-Ser-Ile-Lys-Gly- and -Ala-Asn-Arg-Tyr-Leu-Ala-Met-Lys-Glu-Asp-Gly-Arg-Leu- and having 100 to 240 amino-acid residues in 1.5 and 6 hours and in 3 days after infarction and pericardiotomy started. ^ EFFECT: use of the invention allows restructuring the forming connective tissue due to changing of the polypeptide sequence concentration in certain distances of a pathological process and thereby reducing fibrosis following myocardial infarction and pericardiotomy. ^ 4 cl, 2 tbl, 5 dwg, 2 ex |
申请公布号 |
RU2392960(C1) |
申请公布日期 |
2010.06.27 |
申请号 |
RU20080138512 |
申请日期 |
2008.09.26 |
申请人 |
UCHREZHDENIE ROSSIJSKOJ AKADEMII MEDITSINSKIKH NAUK NAUCHNYJ TSENTR REKONSTRUKTIVNOJ I VOSSTANOVITEL'NOJ KHIRURGII SIBIRSKOGO OTDELENIJA RAMN (NTSRVKH SO RAMN) |
发明人 |
SHURYGIN MIKHAIL GENNAD'EVICH;SHURYGINA IRINA ALEKSANDROVNA;DREMINA NATAL'JA NIKOLAEVNA |
分类号 |
A61K38/16;A61K39/395;A61P43/00 |
主分类号 |
A61K38/16 |
代理机构 |
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地址 |
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