| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: present invention relates to phosphoindoles of formulae (A) and (B) and their use in treating retroviral infections, especially HIV infections, including in form of pharmaceutically acceptable salts, N-oxides, quaternary amines, stereochemical isomers and tautomers and , where Z is C(=O)-NH2; X is an optionally substituted phenyl; Y is O-alkyl; R6' and R7' denote H; W can be O or S; R5' can be a halogen, methyl, ethyl or CF3; R4' can be H, halogen, methyl, ethyl or CF3; R1 can be H or S(O)2-Ph; R2'', R3'', R4'', R5'' and R6'' can be H, halogen, CN, OH, alkoxy, SH, alkylthio, phenyl, CF3, CH2OH, alkyl, halogenalkyl, cyanoalkyl, hydroxyalkyl, benzyloxyalkyl, alkynyl, alkenyl, cyanoalkynyl, cyanoalkenyl. ^ EFFECT: design of novel antiviral preparations. ^ 20 cl, 10 ex, 5 tbl |
