| 摘要 |
Disclosed is a dosage form comprising an active agent, an adsorbent, and an adverse agent, wherein at least a majority of the adverse agent is adsorbed onto the adsorbent, and wherein the adverse agent is an antagonist of the active agent or wherein the adverse agent causes vomiting, nausea, or diarrhoea, when absorbed into an animal's or patient's bloodstream. Also disclosed is an oral dosage form comprising a plurality of first particles comprising an opioid agonist and a plurality of second particles comprising an adsorbent and an opioid antagonist, wherein at least a majority of the opioid antagonist is adsorbed onto the adsorbent and wherein the first particles provide a controlled release of the opioid agonist upon oral administration to a patient. Also disclosed is a method for preparing a dosage form, comprising:providing an adsorbent;providing a liquid comprising an adverse agent; contacting the adsorbent with the liquid comprising the adverse agent for sufficient time to allow at least a portion of the adverse agent to adsorb onto the adsorbent;separating the adsorbent from the liquid phase; and optionally, washing the adsorbent, or comprising providing an adsorbent; providing a liquid comprising an adverse agent; adding the adsorbent to a fluidized bed; fluidizing the adsorbent; spraying the liquid onto the fluidized adsorbent; and optionally, drying the adsorbent. |
