DYNACTIN-1/p150glued AS A TARGET FOR TUMOR DIAGNOSIS AND THERAPY AND A METHOD FOR IDENTIFYING TARGETABLE DISEASE-RELATED PROTEINS

摘要

The present invention relates to dynactin-1/p150glued for use as a targetable protein in the treatment or diagnosis of disorders that involve membranous expression of dynactin-1/p150glued. Diagnosis is suitably effected by detecting the presence of dynactin-1/p150glued in the body or a bodily tissue or fluid, whereas treatment is effected by targeting dynactin-1/p150glued for delivery of therapeutics to the site where treatment is needed. The invention further relates to the use of molecules that bind dynactin-1/p150glued, a nucleic acid encoding dynactin-1/p150glued or a ligand of dynactin-1/p150glued for the preparation of a therapeutical composition for the treatment or diagnosis of disorders that involve expression of dynactin-1/p150glued Dl. The disorders comprise disorders in which dynactin-1 P150/glued is expressed on the luminal surface of blood vessels in tumors and other pathologies which are characterized by membranous expression of dynactin-1/p150glued on blood vessels.