摘要 |
<p>By forming a salt from a non-optically active acid and (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline represented by formula (1): (1) that comprises (R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline as an impurity, and by crystallizing, salt crystals of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline that is represented by formula (2a): (2a) (in formula (2a), An- represents a non-optically active carboxylate anion, non-optically active sulfonate anion, non-optically active phosphonate anion, chloride anion, bromide anion, nitrate anion, hydrogen sulfate anion or perchlorate anion. The n of An- represents the valence of the anion) are manufactured. By then treating the salt crystals with a base, (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline is manufactured.</p> |