发明名称 |
METHOD FOR PRODUCING DIAMINE DERIVATIVE |
摘要 |
<p>Provided is a method for producing a compound represented by formula (A) including: (a) a step of mixing a compound represented by formula (B) with p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate in an amount of less than one molar equivalent relative to the compound represented by formula (B) in a solvent while heating; (b) a step of adding p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to the resulting mixed liquid while cooling, wherein the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to be added is added in an amount such that the total molar equivalent of the added p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate and the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate in step (a) is one molar equivalent or more relative to the compound represented by formula (B); and (c) a step of obtaining a compound represented by formula (A) by crystallization.</p> |
申请公布号 |
WO2010071121(A1) |
申请公布日期 |
2010.06.24 |
申请号 |
WO2009JP70874 |
申请日期 |
2009.12.15 |
申请人 |
DAIICHI SANKYO COMPANY,LIMITED;KOYAMA, TAKEO |
发明人 |
KOYAMA, TAKEO |
分类号 |
C07D513/04;A61K31/444;A61P7/02 |
主分类号 |
C07D513/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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