发明名称 METHOD FOR PRODUCING DIAMINE DERIVATIVE
摘要 <p>Provided is a method for producing a compound represented by formula (A) including: (a) a step of mixing a compound represented by formula (B) with p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate in an amount of less than one molar equivalent relative to the compound represented by formula (B) in a solvent while heating; (b) a step of adding p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to the resulting mixed liquid while cooling, wherein the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to be added is added in an amount such that the total molar equivalent of the added p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate and the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate in step (a) is one molar equivalent or more relative to the compound represented by formula (B); and (c) a step of obtaining a compound represented by formula (A) by crystallization.</p>
申请公布号 WO2010071121(A1) 申请公布日期 2010.06.24
申请号 WO2009JP70874 申请日期 2009.12.15
申请人 DAIICHI SANKYO COMPANY,LIMITED;KOYAMA, TAKEO 发明人 KOYAMA, TAKEO
分类号 C07D513/04;A61K31/444;A61P7/02 主分类号 C07D513/04
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