发明名称 |
Phl p 5a derivatives having reduced allergeneity and retained t-cell reactivity |
摘要 |
The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.
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申请公布号 |
US2010158955(A1) |
申请公布日期 |
2010.06.24 |
申请号 |
US20040559272 |
申请日期 |
2004.05.06 |
申请人 |
WALD MARTIN;CROMWELL OLIVER;NANDY ANDREAS;KAHLERT HELGA;WEBER BERNHARD;FIEBIG HELMUT |
发明人 |
WALD MARTIN;CROMWELL OLIVER;NANDY ANDREAS;KAHLERT HELGA;WEBER BERNHARD;FIEBIG HELMUT |
分类号 |
A61K39/35;A61K38/16;A61P37/08;C07H21/04;C07K14/415;C12N5/00;C12N15/63;C12P21/00 |
主分类号 |
A61K39/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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