| 发明名称 |
PYRIMIDIN- 2 -YLAMINO DERIVATIVES AND THEIR USE TO TREAT INFLAMMATION |
| 摘要 |
<p>Compounds of formula (I) modulate JNK wherein X1 and X2 are each simultaneously N or CH; X3 is CH-R2 or N-SO2R, where R is lower alkyl; R1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radicals; R2 is formula (II), where R3 is H, lower acyl, or an amino acid, or a pharmaceutically acceptable salt thereof.</p> |
| 申请公布号 |
WO2010069833(A1) |
申请公布日期 |
2010.06.24 |
| 申请号 |
WO2009EP66707 |
申请日期 |
2009.12.09 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG;GONG, LEYI;JAHANGIR, ALAM;REUTER, DEBORAH CAROL |
发明人 |
GONG, LEYI;JAHANGIR, ALAM;REUTER, DEBORAH CAROL |
| 分类号 |
C07D401/14;A61K31/506;A61P29/00;C07D401/04;C07D403/14;C07D405/14;C07D409/14;C07D413/14 |
主分类号 |
C07D401/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
