MARKERS FOR DETECTING PREDISPOSITION FOR RISK, INCIDENCE AND PROGRESSION OF OSTEOARTHRITIS

摘要

The present invention relates to a method for the detection of osteoarthritis (OA) or for detection of the risk for developing OA or progression of OA comprising detecting the presence of one or more single nucleotide polymorphisms (SNPs) selected from the group consisting of rs3815148, rs873598, rs10248619, rs10465850, rs12402320 and SNPs in linkage disequilibrium therewith and/or detecting the differential expression of a gene product from one or more of the genes selected from the group consisting of JAK1, KCNN3, GRB10, COG5, AK3L1, DNAJC6, PRKAR2B, HBP1, GPR22, C10orf46, PRLHR, and DUS4L. Further part of the invention are the use of these genes and/or gene products as target for drug development and pharmaceutical compounds for the prevention or therapy of osteoarthritis.