The invention provides agents that modulate the effect of a two pore calcium channel (TPC) polypeptide for use in the treatment or prophylaxis of a condition, disease or disorder associated with NAADP receptor-mediated biological activity. The invention also provides methods of identifying agents that modulate the effect of NAADP receptor mediated biological activity, and kits for use in such methods. Methods for the treatment or prophylaxis of a condition, disease or disorder associated with NAADP receptor- mediated biological activity are also provided.
申请公布号
WO2010030840(A3)
申请公布日期
2010.06.24
申请号
WO2009US56602
申请日期
2009.09.11
申请人
ISIS INNOVATION LTD;THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION;GALIONE, ANTONY;PARRINGTON, JOHN;ZHU, MICHAEL, XI