SERINE PROTEASE DERIVATIVES AND USES IN THE PREVENTION OR THE TREATMENT OF BLOOD COAGULATION DISORDERS
摘要
The present invention relates to chimeric derivatives of serine protease zymogen containing the activation peptide of factor X or a fragment thereof for improving the half- life of said derivatives. Preferably, said chimeric derivatives are protein C and factor X derivatives. The invention also relates to said derivatives for the prevention or treatment of blood coagulation disorders.
申请公布号
WO2010070137(A1)
申请公布日期
2010.06.24
申请号
WO2009EP67632
申请日期
2009.12.21
申请人
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);CHRISTOPHE, OLIVIER;DENIS, CECILE;CHEREL, GHISLAINE;GUEGUEN, PAUL
发明人
CHRISTOPHE, OLIVIER;DENIS, CECILE;CHEREL, GHISLAINE;GUEGUEN, PAUL