发明名称 |
NOVEL LACTAMS AND USES THEREOF |
摘要 |
Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid &bgr; protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid &bgr; protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. |
申请公布号 |
US2010160627(A1) |
申请公布日期 |
2010.06.24 |
申请号 |
US20090359465 |
申请日期 |
2009.01.26 |
申请人 |
ASTRAZENECA AB |
发明人 |
DEMBOFSKY BRUCE THOMAS;JACOBS ROBERT;OHNMACHT CYRUS |
分类号 |
C07D267/02;A61K38/00;A61P25/28;C07D223/16;C07D267/10;C07D267/14;C07D281/06;C07D281/10;C07D405/04;C07D417/12;C07D417/14;C07K5/06 |
主分类号 |
C07D267/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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