发明名称 |
Method and System for Genotyping Samples in a Normalized Allelic Space |
摘要 |
Aspects of the present invention describe an apparatus and method for generating genotype calls for a sample. The genotyping initially models allelic signal response into an allelic model having one or more model parameters for an identified one or more sources of systematic variation. The model and parameters are then used to transform the allelic signals to a normalized normalized allelic space that serves to compensate for the one or more sources of systematic variation. By compensating for the systematic variation in this manner, the genotype for the sample is readily determined based upon its relationship to the representation of the allelic signals in normalized allelic space and in accordance with the allelic model.
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申请公布号 |
US2010161237(A1) |
申请公布日期 |
2010.06.24 |
申请号 |
US20090551438 |
申请日期 |
2009.08.31 |
申请人 |
LIFE TECHNOLOGIES CORPORATION |
发明人 |
PRATT MARK R.;HOLDEN DAVID |
分类号 |
G06F19/00;G01N33/48;G06F17/18 |
主分类号 |
G06F19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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