| 摘要 |
The invention generally relates to the application of imaging techniques, in particular positron emission tomography (PET) or single photon emission tomography (SPECT), in the assessment of physiological parameters in a subject. The compounds of the present invention were shown to be cell membrane permeant and to have a specific binding affinity (or substrate affinity) for the carbonic anhydrases type I and II, and are accordingly useful for the in vivo and in vitro labeling of erythrocytes (RBC). It is accordingly an object of the present invention to provide said novel compounds, in particular the radio labeled variants thereof, and their use in imaging techniques to perform the assessment of physiological parameters, such as blood volume measurements, or blood flow measurements. |
