TOPICAL COMPOSITIONS COMPRISING AT LEAST ONE ACTIVE INGREDIENT POORLY SOLUBLE IN WATER AND BIOPOLYMERS SUCH AS HYALURONIC ACID WITH A PKA-VALUE BETWEEN 5-7

摘要

The present invention relates to compositions comprising one or more active ingredients poorly soluble in water and an biopolymer having at least one carboxylic group, selected from acid polysaccharides such as hyaluronic acid, alginic acid, polymaleic acid or a derivative thereof having a pKa-value of between 5 and 7 in a water or water - alcoholic mixture. Surprisingly such active ingredients remain in a suitable (solvated) form in the composition without rapid crystallisation of the active/s. Moreover when topically applied to skin or parts thereof, e.g. nails, hair and scalp in need of a treatment, the compositions as described surprisingly form an essentially anti-abrasive film which can be removed by action of water. The compositions have a good skin compatibility with excellent adhesive properties and are especially suitable for treatment of skin, hair or nails in need of an anti-infective, anti-mycotic, anti-inflammatory / or related treatment.