发明名称 |
SMALL MOLECULE ANTAGONISTS OF BACTERIAL QUORUM-SENSING RECEPTORS |
摘要 |
A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote Caenorhabditis elegans from quorum-sensing-mediated killing by the bacterial pathogen Chromobacterium violaceum. The saving of C. elegans demonstrates the use of these molecules as small molecule antimicrobials. |
申请公布号 |
US2010160423(A1) |
申请公布日期 |
2010.06.24 |
申请号 |
US20090643574 |
申请日期 |
2009.12.21 |
申请人 |
|
发明人 |
BASSLER BONNIE L.;SWEM LEE R.;ULRICH SCOTT M.;O'LOUGHLIN COLLEEN T. |
分类号 |
A61K31/381;A01N43/08;A01N43/10;A01P1/00;A61K31/341;A61P31/04;C07D307/33;C07D333/36 |
主分类号 |
A61K31/381 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|