A METHOD OF PRODUCING INSULINOTROPIC GLP-1 (7-36) POLYPEPTIDE AND/OR GLP-1 ANALOGS

摘要

The present invention relates to a method of producing glucagon-like peptide 1(GLP-1)7-36 and an GLP-1 analogue by consecutive genes, and peptide produced by said method. In the present invention, 1-32 GLP-1(7-36) genes or GLP-1 analogue genes can be expressed in tandem, subsequently, the target peptide can be obtained by several steps including fusion protein lysis, isolation and purification. The present invention can decrease production cost dramatically, also can produce GLP-1(7-36) and GLP-1 analogue in large scale.