GENETIC THERAPY CARRIED OUT BY SILENCING THE WT1 GENE WITH SEQUENCES OF INTERFERING RNAS THROUGH POLYETHYLAMINE, WHICH ARE AEROSOL ADMINISTERED FOR TREATING LUNG CANCER.

摘要

The present invention refers to a pharmaceutical composition specifically administered in aerosol, which induces apoptosis in the pulmonary tissue of mammals via intrinsic, causing a significant increase in the survival of treated mammals suffering from lung cancer. Described is the design and construction of interfering RNA sequences for silencing in an efficient manner the WT1 gene, also describing the results of the aerosol administration and the application in lung cancer treatments.