发明名称 |
Adenoviral vectors and uses thereof |
摘要 |
The present invention relates to recombinant adenoviral vectors based on adenoviruses that encounter pre-existing immunity in a minority of the human population and which harbor a chimeric capsid. The chimeric capsid comprises fiber proteins that have at least the knob domain of a human adenovirus that binds to the Coxsackievirus and Adenovirus Receptor (CAR) and a hexon protein from an adenovirus serotype that encounters pre-existing immunity in a low percentage of the human population.
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申请公布号 |
US7741099(B2) |
申请公布日期 |
2010.06.22 |
申请号 |
US20050665276 |
申请日期 |
2005.10.12 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER INC.;CRUCELL HOLLAND B.V. |
发明人 |
HAVENGA MENZO JANS EMCO;BAROUCH DAN H. |
分类号 |
C12N7/04;A61K39/23 |
主分类号 |
C12N7/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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