发明名称 |
ORAL CAPSULE FORMULATION WITH INCREASED PHYSICAL STABILITY |
摘要 |
A formulation for a stabilized capsule for oral administration of a hydrophobic pharmaceutically active agent; comprising a non-aqueous solubilizer selected from 2-pyrrolidone, N-alkylpyrrolidones and combinations thereof; and a capsule stabilizing agent selected from mono-,di-and triglycerides, mono-and di-fatty esters of polyethylene glycol, fatty acids and combinations thereof wherein capsule integrity is maintained for at least 24 hours is disclosed.
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申请公布号 |
CA2466868(C) |
申请公布日期 |
2010.06.22 |
申请号 |
CA20022466868 |
申请日期 |
2002.12.20 |
申请人 |
SHIRE LABORATORIES INC. |
发明人 |
SHOJAEI, AMIR H.;IBRAHIM, SCOTT A.;BURNSIDE, BETH A. |
分类号 |
A61K9/48;A61K9/32;A61K47/12;A61K47/14;A61K47/22;A61K47/34 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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