发明名称 TIE-2 LIGANDS, METHODS OF MAKING AND USES THEREOF
摘要 The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
申请公布号 CA2216963(C) 申请公布日期 2010.06.22
申请号 CA19962216963 申请日期 1996.04.05
申请人 REGENERON PHARMACEUTICALS, INC. 发明人 DAVIS, SAMUEL;BRUNO, JOANNE;GOLDFARB, MITCHELL;ALDRICH, THOMAS H.;MAISONPIERRE, PETER C.;RADZIEJEWSKI, CZESLAW;JONES, PAMELA F.;YANCOPOULOS, GEORGE D.
分类号 C12N15/18;G01N33/53;A61K;A61K38/00;A61K38/18;A61K38/19;A61K39/395;A61K45/00;A61K47/48;A61K51/08;A61P3/00;A61P7/00;A61P9/00;A61P35/00;A61P43/00;C07K;C07K14/47;C07K14/475;C07K14/515;C07K14/52;C07K14/71;C07K16/18;C07K16/22;C07K16/42;C07K19/00;C12N;C12N1/20;C12N5/10;C12N15/00;C12N15/09;C12N15/19;C12N15/62;C12N15/63;C12P21/02;C12R1/91;G01N33/15;G01N33/566;G01N33/577 主分类号 C12N15/18
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