发明名称 |
Production of the lipidated form of the peptidoglycan-associated lipoproteins of gram-negative bacteria |
摘要 |
The expression of the lipidated form of the peptidoglycan-associated protein (PAL) of gram-negative bacteria is achieved through the use of a plasmid containing a tightly regulated promoter. A bacterial host cell is transformed, transduced or transfected with such a plasmid. The host cell is then cultured under conditions such that the lipidated recombinant PAL is expressed. The lipidated recombinant PAL is included in an antigenic composition administered to a mammalian host to immunize against a gram-negative bacterium.
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申请公布号 |
US7741076(B2) |
申请公布日期 |
2010.06.22 |
申请号 |
US20080254251 |
申请日期 |
2008.10.20 |
申请人 |
WYETH HOLDINGS CORPORATION |
发明人 |
METCALF BENJAMIN J. |
分类号 |
C12N15/09;A61K38/00;A61K39/00;A61K39/145;A61P11/00;A61P31/00;A61P31/16;C07K14/285;C12N1/21;C12N15/70;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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