发明名称 Benzimidazole-derivatives as factor Xa inhibitors
摘要 The present invention relates to compounds of the formula I, wherein R0, R1, R2, Q, V, G and M are as defined herein. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
申请公布号 US7741341(B2) 申请公布日期 2010.06.22
申请号 US20040849436 申请日期 2004.05.19
申请人 SANOFI-AVENTIS DEUTSCHLAND GMBH 发明人 NAZARE MARC;WAGNER MICHAEL;WEHNER VOLKMAR;MATTER HANS;URMANN MATTHIAS;RITTER KURT
分类号 A61K31/4523;C07D235/24;C07D401/12;C07D401/14;C07D403/12;C07D409/14;C07D413/12;C07D413/14;C07D417/14;C07D471/04;C07D473/08;C07D495/04 主分类号 A61K31/4523
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