COMPLEX OF ANTIOXIDANT AND HYALURONIC ACID HAVING IMPROVED STABILITY

摘要

PURPOSE: An antioxidant-hyaluronic acid composite is provided to enhance stability of antioxidant and to block antioxidant deterioration. CONSTITUTION: An antioxidant-hyaluronic acid is manufactured by reacting antioxidant and hyaluronic acid under the presence of 3-dimethyl-aminopropyl-N-ethyl carbodimide. The antioxidant is retinol, coenzyme Q10, alpha-tocopherol, ascorbic acid, butylated hydroxyl toluene, genistein, propyl gallate, epigallocatechingallate, or gallocatechin gallate. The reaction is performed under the presence of acid. The acid is hydrochloric acid, acetic acid, sulfonic acid, phosphoric acid. A method for manufacturing the antioxidant-hyaluronic acid composite comprises: a step of reacting hyaluronic acid and adipic acid dihydrazide under the presence of 3-dimethyl-aminopropyl-N-ethyl carbodimide; and a step of reacting alpha-lipoic acid or glutathione under the presence of the product and 3-dimethyl-aminopropyl-N-ethyl carbodimide.