PYRIDINIUM OXIME DERIVATIVES CONTAINING FLUORINE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PURPOSE: A fluorine-containing pyridinium oxime derivative is provided to reactivate acetylcholine esterase and to use as a detoxifying agent. CONSTITUTION: A fluorine-containing pyridinium oxime derivative is denoted by chemical formula 1. In chemical formula, R is hydrogen or fluorine; Y is CH=N-OH or C(=O)-NH_2, at least one among Y is CH=N-OH; and X is Cl, Br, I, OS(=O)_2CH_3 or OS(=O)_2CF_3. An detoxifying agent against organic phosphorus chemical contains fluorine-containing pyridinium oxime derivative as an active ingredient. A therapeutic agent to organic phosphorus agricultural chemical contains fluorine-containing pyridinium as an active ingredient.