3-CARBAMOYL-2-PYRIDONE DERIVATIVES

摘要

FIELD: chemistry. ^ SUBSTANCE: invention refers to compounds of the formula (I): , where R1 is C1-C8alkyl optionally substituted with one to three substitutes selected out of substitute group A; R2 is C1-C6alkyl or C1-C6alkoxyC1-C6alkyl; R3 is C1-C6alkyl or C1-C6alkoxy; or R2 and R3 together with adjoining carbon atoms form optionally substituted non-aromatic 5-10-member carbon ring; R4 is hydrogen; G is group represented by the formula: or the rest as provided in the invention claim; and to pharmaceutical composition, application of claimed compounds, and method of atopic dermatitis prevention or treatment. ^ EFFECT: novel compounds useful as atopic dermatitis treatment medication and antipruritic medicines. ^ 24 cl, 75 ex, 290 tbl