发明名称 |
METHODS OF INHIBITING VASCULAR PERMEABILITY AND APOPTOSIS |
摘要 |
<p>Agonists of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial sphingosine-1-phosphate receptor agonists are employed in methods of treating a mammal for vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels. The sphingosine-1-phosphate receptor agonists can be used for the manufacture of a medicament for treating vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels</p> |
申请公布号 |
PT1643983(E) |
申请公布日期 |
2010.06.18 |
申请号 |
PT20040776717T |
申请日期 |
2004.06.18 |
申请人 |
THE UNIVERSITY OF CONNECTICUT |
发明人 |
TIMOTHY HLA;TERESA SANCHEZ;JI-HYE PAIK;KEVIN P. CLAFFEY |
分类号 |
A61K31/133;A61K31/00;A61P9/00 |
主分类号 |
A61K31/133 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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