发明名称 |
BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER |
摘要 |
It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.
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申请公布号 |
US2010152493(A1) |
申请公布日期 |
2010.06.17 |
申请号 |
US20060993840 |
申请日期 |
2006.06.27 |
申请人 |
SHIBATA HIROYUKI;IWABUCHI YOSHIHARU;OHORI HISATSUGU;YAMAKOSHI HIROYUKI;KAKUDO YUICHI |
发明人 |
SHIBATA HIROYUKI;IWABUCHI YOSHIHARU;OHORI HISATSUGU;YAMAKOSHI HIROYUKI;KAKUDO YUICHI |
分类号 |
C07C49/217 |
主分类号 |
C07C49/217 |
代理机构 |
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地址 |
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