发明名称 |
MODIFICATION OF NUCLEIC ACID VECTORS |
摘要 |
The present invention provides a polymer modified nucleic acid vector in which the nucleic acid vector is covalently linked to a polymer, which polymer comprises one or more positively charged quaternary amino groups, wherein the nucleic acid vector is a micro-organism selected from the group consisting of a virus, a bacteria or a bacteriophage, a fungus, a spore, a eukaryotic cell nucleus or other micro-organism fragment or a component containing genetic information, and wherein (a) the polymer and/or the linkages between it and the nucleic acid vector are hydrolytically, reducibly or enzymatically degradable; and/or (b) wherein each of the positively charged quaternary amino groups is linked to the polymer backbone via one or more degradable or biodegradable linkages. |
申请公布号 |
CA2744938(A1) |
申请公布日期 |
2010.06.17 |
申请号 |
CA20092744938 |
申请日期 |
2009.12.11 |
申请人 |
PSIOXUS THERAPEUTICS LIMITED |
发明人 |
SEYMOUR, LEONARD WILLIAM;FISHER, KERRY;ULBRICH, KAREL;SUBR, VLADIMIR |
分类号 |
C12N15/85;A61K48/00;C12N7/01;C12N15/00;C12N15/861 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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