MEK MUTATIONS CONFERRING RESISTANCE TO MEK INHIBITORS
摘要
The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of MEK. In particular embodiments, the invention concerns mutations in a MEK sequence that confer resistance to a MEK inhibitor. Identification of such mutations in a MEK sequence allows the identification and design of second-generation MEK inhibitors. Methods and kits for detecting the presence of a mutant MEK sequence in a sample are also provided.
申请公布号
WO2010068738(A1)
申请公布日期
2010.06.17
申请号
WO2009US67472
申请日期
2009.12.10
申请人
DANA-FARBER CANCER INSTITUTE, INC.;GARRAWAY, LEVI;EMERY, CAROLINE;GARCIA-ECHEVERRIA, CARLOS
发明人
GARRAWAY, LEVI;EMERY, CAROLINE;GARCIA-ECHEVERRIA, CARLOS