摘要 |
There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer.
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申请人 |
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO);PEVARELLO, PAOLO;GARCIA COLLAZO, ANA MARIA;RODRIGUEZ HERGUETA, ANTONIO;SALUSTE, CARL-GUSTAF PIERRE;RAMOS LIMA, FRANCISCO JAVIER;GONZALEZ CANTALAPIEDRA, ESTHER;OYARZABAL SANTAMARINA, JULEN |
发明人 |
PEVARELLO, PAOLO;GARCIA COLLAZO, ANA MARIA;RODRIGUEZ HERGUETA, ANTONIO;SALUSTE, CARL-GUSTAF PIERRE;RAMOS LIMA, FRANCISCO JAVIER;GONZALEZ CANTALAPIEDRA, ESTHER;OYARZABAL SANTAMARINA, JULEN |