发明名称 |
TETRAHYDROTRIAZINE COMPOUNDS FOR TREATING DISEASES ASSOCIATED WITH AMPK ACTIVITY |
摘要 |
<p>The invention relates to compounds of formula (I) wherein the radicals R1 to R6 have the meaning according to claim 1, and/or physiologically acceptable salts thereof, for the prophylactic or therapeutic treatment and/or monitoring of physiological and/or pathological conditions that are associated with the activity of AMP-activated protein kinase (AMPK). Another object of the invention concerns the use of said compounds for enhancing glucose homeostasis, improving podocytopathy and/or decreasing the production of reactive oxygen species (ROS). The invention also relates to a method for in-vitro diagnosing diabetic nephropathy and a method for screening compounds that reduce podocytopathy, in each case by applying synaptopodin as biomarker.</p> |
申请公布号 |
CA2745854(A1) |
申请公布日期 |
2010.06.17 |
申请号 |
CA20092745854 |
申请日期 |
2009.12.11 |
申请人 |
POXEL |
发明人 |
CRAVO, DANIEL;HALLAKOU-BOZEC, SOPHIE;MESANGEAU, DIDIER;ELBAWAB, SAMER |
分类号 |
C07D251/10;A61K31/53;A61P3/10 |
主分类号 |
C07D251/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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