发明名称 |
MODULATION OF THE VPS10P-DOMAIN RECEPTORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE |
摘要 |
<p>The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3, in an animal and methods for preparation of a medicament for the treatment of abnormal plasma lipid concentrations and associated diseases and/or disorders.The modulation is carried out by inhibiting or promoting the binding of ligands to the Vps10p-domain receptor. In vitro and in vivo methods for screening for agents capable of modulation of said Vps10p-domain receptor activity are also provided. The invention furthermore relates to methods of altering expression of said receptors in vivo.</p> |
申请公布号 |
WO2009140972(A3) |
申请公布日期 |
2010.06.17 |
申请号 |
WO2009DK50115 |
申请日期 |
2009.05.20 |
申请人 |
H. LUNDBECK A/S;NYKJAER, ANDERS;FUGLSANG KJOELBY, MADS |
发明人 |
NYKJAER, ANDERS;FUGLSANG KJOELBY, MADS |
分类号 |
A61K31/00;A61K38/06;A61K38/08;A61K45/06;A61P3/06;C07K16/28;G01N33/566;G01N33/92 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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