NEW IMMUNOGENIC LIPOPEPTIDE COMPRISING T-HELPER EPITOPE AND CYTOTOXIC T LYMPHOCYTE (CTL) EPITOPE

摘要

PROBLEM TO BE SOLVED: To provide synthetic immunogenic lipopeptide molecules comprising T-helper epitope and CTL epitope, and to provide methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular CTL epitopes.

SOLUTION: There is provided highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog (preferably to the terminal side-chain group of an internal diamino acid residue). Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the CTL epitope.

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