发明名称 |
Influenza inhibiting compositions and methods |
摘要 |
The present invention provides peptides, peptide analogs, peptide derivatives and pharmaceutical compositions useful for treating or preventing influenza infections or preventing the person-to-person transmission of an influenza infection. A peptide of the invention comprises an influenza virus-cell fusion inhibiting portion of the fusion initiation region (FIR) of a wild-type influenza hemagglutinin 2 protein or a variant thereof. In a preferred embodiment, a peptide of the invention consists of 8 to 40 consecutive amino acid residues a portion of a wild-type influenza hemagglutinin 2 protein or a variant thereof, the portion of the protein comprising the FIR of the protein and up to five amino acid residues on the amino-terminal and carboxy-terminal sides of the FIR.
|
申请公布号 |
US2010152109(A1) |
申请公布日期 |
2010.06.17 |
申请号 |
US20080452240 |
申请日期 |
2008.06.25 |
申请人 |
GARRY ROBERT F;WILSON RUSSELL B |
发明人 |
GARRY ROBERT F.;WILSON RUSSELL B. |
分类号 |
A61K38/16;A61K38/08;A61K38/10;C07K7/06;C07K7/08;C07K14/11;C07K16/08 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|