2,4-DOUBLE SUBSTITUTED-5-AMINOCARBONYL-1,3-THIAZOLE DERIVATIVE FOR TREATING AGENT OF INFLAMMATION-ASSOCIATED DISEASE, METHOD FOR PRODUCING THE SAME, TREATING AGENT OF INFLAMMATORY-ASSOCIATED DISEASE INDUCED BY SPC RECEPTOR ACTIVITY BY CONTAINING THE SAME AS ACTIVE COMPONENT, SKIN EXTERNAL AGENT FOR SCAR FORMATION INHIBITOR AFTER EXTERNAL WOUND AND WOUND HEALING PROMOTION, AND ANGIOGENESIS INHIBITOR AT INSIDE OF TUMOR

摘要

PROBLEM TO BE SOLVED: To provide a treating agent of inflammatory-associated diseases induced by an SPC receptor activity.

SOLUTION: This 2,4-double substituted-5-aminocarbonyl-1,3-thiazole derivative expressed by general formula 1 [wherein, R1to R4are each 1-10C linear or side chain alkyl, cycloalkyl or the like], or a pharmaceutically acceptable salt of the same is provided. The derivative or pharmaceutically acceptable salt of the same is useful as a treating agent effective for the inflammatory-associated diseases such as the inflammation appearing in atopic dermatitis and other diseases, and pruritus or skin infectious diseases.

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