NOVEL PYRIDINYL ACRYLAMIDE DERIVATIVES

摘要

The present application discloses pyridinyl acrylamide derivatives of the formula (I) wherein X is opt.subst. pyrid-3-yl, pyrid-4-yl; A is -C(=O)-, -S(=O)2-, -C(=S)-, -P(=O)(R5)- (R5 is C1-6-alkyl, C1-6-alkoxy, hydroxy); B is a single bond, -O-; D is a single bond, -O-, -CR7R8-, -NR9-; m is 0-12, n is 0-12, m+n is 1-20. The compounds are useful for the inhibiting of the enzyme nicotinamide phosphoribosyltransferase (NAMPRT), and to medical use of such pyridinyl acrylamide derivatives.