MEANS AND METHODS FOR INFLUENCING ELECTRICAL ACTIVITY OF CELLS

摘要

The invention provides means and methods for providing a cell with a spontaneous electrical activity and means and methods for increasing the depolarization rate of a cell having a spontaneous electrical activity. Means and methods are provided comprising: - providing a cell with a compound capable of providing and/or increasing a pacemaker current If, and - diminishing electrical coupling between said cell and surrounding cells and/or reducing the inward rectifier current IK1 of said cell, and or increasing the availability of lNa at depolarized potentials, preferably using overexpression of additional sodium channels.