| 摘要 |
<p>Disclosed is a compound represented by the Structural Formula (I); Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or -C(RR)-. Rand Rare independently an aryl group or a substituted aryl group, Rand Rare independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R- Rare independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. Rand Rare each independently -H, an aliphatic or substituted aliphatic group, or Ris -H and Ris a substituted or unsubstituted aryl group, or, Rand R, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is =O or =S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with taxol or an analog of taxol.</p> |
