发明名称 |
METHOD FOR SELECTIVELY AMPLIFYING, DETECTING OR QUANTIFYING HYPOMETHYLATED TARGET DNA |
摘要 |
Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment. |
申请公布号 |
EP2195449(A1) |
申请公布日期 |
2010.06.16 |
申请号 |
EP20080783612 |
申请日期 |
2008.08.05 |
申请人 |
THE CHINESE UNIVERSITY OF HONG KONG |
发明人 |
LO, YUK MING DENNIS;TONG, YU KWAN;CHIU, WAI KWUN ROSSA;DING, CHUNMING |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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