发明名称 |
METHOD FOR IDENTIFYING A LIGAND CAPABLE OF SELECTIVELY MODULATING A FUNCTIONAL CASCADE INVOLVING A TARGET, AND USES THEREOF FOR HIGH-THROUGHPUT SCREENING OF MOLECULES OF INTEREST |
摘要 |
<p>The invention concerns a method for identifying a ligand capable of selectively modulating a functional cascade involving a target, and uses thereof for high-throughput screening of molecules of interest, in particular therapeutic (medicine). Said method comprises at least the following steps: a) identifying an antibody or an antibody fragment comprising at least one of the variable domains of an immunoglobulin chain, capable of binding to said target and modulating said functional cascade involving said target; b) screening from a bank of molecules, ligands modulating the bond between said target and the antibody or antibody fragment identified in a); and c) identifying among said modulating ligands obtained in b), those capable of modulating said functional cascade.</p> |
申请公布号 |
EP1743178(B1) |
申请公布日期 |
2010.06.16 |
申请号 |
EP20050762419 |
申请日期 |
2005.04.25 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE DE MONTPELLIER I;UNIVERSITE DE MONTPELLIER II |
发明人 |
MARTINEAU, PIERRE;DARIAVACH, PIONA |
分类号 |
G01N33/68;G01N33/50 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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