| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound showing a high optical selectivity in an optically selective esterification of a racemic alcohol and useful as an optically active base catalyst. SOLUTION: This 4-aminopyridine derivative is a compound of formula I (R1, R2 are each a 1-8C alkyl, phenyl or a phenyl substituted with 1-3 groups of a 1-8C alkyl), e.g. (R)-(2'S, 5'S)-4-[2', 5'-bis(3",-5"-diphenylphenylethyl) pyrrolidino] pyridine. The compound of the formula I is obtained by reacting a racemic (2S*, 5S*)-N-(pmethoxy)benzyl-2, 5-diethynylpyrrolidine with a compound of formula II (e.g.; 3, 5-diphenylphenylbromide) in the presence of cuprous iodide, bis(triphenylphosphine)palladium dichloride and triethylamine, and then passing through various processes. |
