发明名称 |
ENHANCEMENT OF THE EFFICACY OF THERAPEUTIC PROTEINS |
摘要 |
A formulation for administration of at least one therapeutic mammalian protein to a mammal or a protein selected from the group, and for enhancing the absorption, distribution and release of the at least one therapeutic mammalian protein in or on the mammal, comprising at least one therapeutic mammalian protein in a micro-emulsion comprising a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. A method for effective delivery of at least one therapeutic mammalian protein to a mammal and for enhancing the therapeutic efficacy of such at least one therapeutic mammalian protein, comprising the step of administering the at least one therapeutic mammalian protein to the mammal in such a formulation. |
申请公布号 |
EP2194970(A2) |
申请公布日期 |
2010.06.16 |
申请号 |
EP20080789190 |
申请日期 |
2008.07.04 |
申请人 |
THE NORTH WEST UNIVERSITY |
发明人 |
GROBLER, ANNE FREDERICA;KOTZE, ABRAHAM FREDERIK;DU PLESSIS, JEANETTA |
分类号 |
A61K9/107;A61K31/201;A61K31/203;A61K38/00;A61K38/02;A61K38/04;A61K38/16;A61K38/17;A61K47/12;A61K47/14 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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