发明名称 |
SULFONIC ACID SALT COMPOUND OF 4-CARBAMOYL-5-HYDROXY-IMIDAZOLE DERIVATIVE |
摘要 |
<p>The object is to provide a stable SM-108 derivative, which is effective as a carcinostatic agent, particularly an SM-108 derivative having good storage stability. An SM-108 compound having good storage stability can be produced by producing an organic sulfonic acid salt compound of SM-108. Further, a crystalline SM-108 compound containing a trace amount of an organic carboxylic acid can be produced by using an aqueous solution of the organic sulfonic acid salt of SM-108, and by adding an alkali metal salt of an organic carboxylic acid to the aqueous solution to neutralize the aqueous solution and then causing the crystal precipitation in the solution.</p> |
申请公布号 |
EP2196460(A1) |
申请公布日期 |
2010.06.16 |
申请号 |
EP20080830235 |
申请日期 |
2008.09.16 |
申请人 |
MBR CO., LTD.;KATO, NOBUO |
发明人 |
KATO, NOBUO;HIGUCHI, YUSUKE;KONDO, CHIHIRO;SUNAGAWA, MAKOTO |
分类号 |
C07D233/90;A61K31/4164;A61P35/00 |
主分类号 |
C07D233/90 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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